Shuqin Zhang1,
Xin Li1 
,
Yating Bai2,
Lixin Fu1,
Yanjiang Cui1
For correspondence:- Xin Li Email: ai40470770360399@163.com
Accepted: 23 July 2021 Published: 31 August 2021
Citation:
Zhang S, Li X, Bai Y, Fu L, Cui Y.
Puerarin modulates apoptosis of MC3T3-E1 and ATDC5 cells by attenuating the ex
© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the protective effect of puerarin against apoptosis of osteoblasts and chondrocytes.
Methods: Osteoblast-like MC3T3-E1 cells and chondrocyte ATDC5 were used as cellular models. Dexamethasone (Dex) was used to induce cellular stress. Cell viability was determined with cell counting kit-8 (CCK-8) assay. Cell apoptosis and the level of reactive oxygen species (ROS) were also measured. Changes in ERS markers were measured with quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting.
Results: Treatment with puerarin reduced cell viability and increased apoptosis, and inhibited the production of ROS. Furthermore, the ex
Conclusion: Puerarin protected MC3T3-E1 and ATDC5 cells from apoptosis via attenuation of the ex
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